Article

High-Throughput Screening of Candidate Analgesics Using a Patient-Derived Human iPSC Model of Nociception Identifies Putative pain reducing compounds

2024-07-16

Abstract excerpt

<h4>Background: </h4> and purpose: In this study, we applied an induced pluripotent stem cell (iPSC)-based model of inherited erythromelalgia (IEM) to screen a library of 295 small molecules aiming to identify candidate pain-modulating compounds. Experimental approach: Human iPSC-derived nociceptor-like cells, which exhibit action potentials in response to noxious stimulation, were evaluated using whole-cell patch...

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Literature Corpus work: a22af3c7-1376-5fa4-a590-c1abfcbd24ee
DOI: 10.22541/au.172115003.35586564/v1

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