Article

Ectopic engraftment of nociceptive neurons derived from hPSCs for pain relief and joint homeostasis

2025-12-19

Abstract excerpt

<h4>SUMMARY</h4> Chronic pain arises from the interplay of inflammatory signals that activate and sensitize nociceptors within injured tissues. Most analgesics fail clinically due to their mono-targeted mechanisms. Here, we apply human pluripotent stem cell–derived nociceptive neurons (hPSC-NNs) as therapeutic agents for osteoarthritis, targeting both pain and joint degeneration. We generated sensory neurons from...

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Literature Corpus work: 050fdb43-5fad-5396-b735-a275d6e4771e
DOI: 10.64898/2025.12.16.694733

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