Article

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons

2024-08-24

Abstract excerpt

Peripheral sensory neurons are a primary effector in pain neurotransmission, and have become a useful cellular model for the study of pain. While rodent tissue has historically served as a source of these neurons, it has become increasingly clear that pain mechanisms in rodents and humans are substantially divergent. Sensory neurons harvested from cadaveric human tissue serve as a superior translational model for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b1fd752f-55ff-5296-937a-5c41d7df750f
DOI: 10.1101/2024.08.23.607310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neuronsDOI 10.1101/2024.08.23.607310Read

A Transcriptomic Comparison of the HD10.6 Human Sensory Neuron-Derived Cell Line with Primary and iPSC Sensory NeuronsSemantic proximity Read

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neuronsSemantic proximity Read

How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a comparison of two protocolsSemantic proximity Read

Single nucleus transcriptomic analysis of human dorsal root ganglion neuronsSemantic proximity Read

Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem CellsSemantic proximity Read

Spatial transcriptomics reveals unique molecular fingerprints of human nociceptorsSemantic proximity Read

Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpressionSemantic proximity Read

Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived NociceptorsSemantic proximity Read

Single-nucleus transcriptomic analysis of human dorsal root ganglion neuronsSemantic proximity Read

Generation of human nociceptor-enriched sensory neurons for the study of pain-related dysfunctionsSemantic proximity Read

Profiling Human iPSC-Derived Sensory Neurons for Analgesic Drug Screening Using a Multi-Electrode ArraySemantic proximity Read

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptorsSemantic proximity Read