Article
Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.
Science translational medicine - 28 Sept 2016
Higgins Sarah J, Purcell Lisa A, Silver Karlee L, Tran Vanessa, Crowley Valerie, Hawkes Michael, Conroy Andrea L, Opoka Robert O, Hay John G, Quaggin Susan E, Thurston Gavin, Liles W Conrad, Kain Kevin C
Abstract excerpt
Cerebral malaria is a leading cause of global morbidity and mortality. Interventions targeting the underlying pathophysiology of cerebral malaria may improve outcomes compared to treatment with antimalarials alone. Microvascular leak plays an important role in the pathogenesis of cerebral malaria. The angiopoietin (Ang)-Tie-2 system is a critical regulator of vascular function. We show that Ang-1 expression and...
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