Article

Self-controlled Sequencing Suggests that Somatic Mutations of Signaling, Transcription and Tumor Suppression Genes are a Precondition for AML Transformation in MDS

2022-01-11

Abstract excerpt

<title>Abstract</title> <p>Background The transformation biology of secondary AML from MDS is still not fully understood. Here, we performed a large cohort of paired self-controlled sequences including target, whole-exome and single cell sequencing to search AML transformation-related mutations (TRMs). Methods 39 target genes from paired samples from 72 patients with MDS who had undergone AML transformation wer...

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Literature Corpus work: fc04a8c7-977e-590d-adf2-2acd0759775e
DOI: 10.21203/rs.3.rs-1142924/v1

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