Article
Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome.
Blood - 10 May 2012
Zhang Su-Jiang, Rampal Raajit, Manshouri Taghi, Patel Jay, Mensah Nana, Kayserian Andrew, Hricik Todd, Heguy Adriana, Hedvat Cyrus, Gönen Mithat, Kantarjian Hagop, Levine Ross L, Abdel-Wahab Omar, Verstovsek Srdan
Abstract excerpt
Leukemic transformation (LT) of myeloproliferative neoplasms (MPNs) is associated with a poor prognosis and resistance to therapy. Although previous candidate genetic studies have identified mutations in MPN patients who develop acute leukemia, the complement of genetic abnormalities in MPN patients who undergo LT is not known nor have specific molecular abnormalities been shown to have clinical relevance in this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.