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Genetic changes during leukemic transformation to secondary acute myeloid leukemia from myeloproliferative neoplasms.

Leukemia research - 1 Jul 2022

Kim TaeHyung, Ahn Jae-Sook, Son Meong Hi, Novitzky-Basso Igor, Yi Seong Yoon, Ahn Seo-Yeon, Jung Sung-Hoon, Yang Deok-Hwan, Lee Je-Jung, Choi Seung Hyun, Lee Ja-Yeon, Moon Joon Ho, Sohn Sang Kyun, Kim Hyeoung-Joon, Zhang Zhaolei, Kim Dennis Dong Hwan

Abstract excerpt

Leukemic transformation (LT) is the main cause of death for patients with myeloproliferative neoplasms (MPNs). To study genetic changes associated with the LT, we performed targeted sequencing in 26 MPN patients including 21 with paired samples. We observed that, besides three driver genes, IDH2 (19%) and ASXL1 (14%) were also frequently mutated at MPN diagnosis. Although variant allele frequencies (VAFs) of...

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PMID: 35609360
DOI: 10.1016/j.leukres.2022.106858

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