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DOCK2 sets the threshold for entry into the virtual memory CD8 <sup>+</sup> T cell compartment by negatively regulating tonic TCR triggering

2019-03-20

Abstract excerpt

The control of cytoskeletal dynamics by Dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified in patients with a recessive form of combined immunodeficiency with defects in T, B and NK cell activation. Surprisingly, we show here that certain immune functions of CD8 + T...

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Literature Corpus work
fc008856-09bb-59fd-b744-b57cae11d294
DOI
10.1101/582486
Open publication

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DOCK2 sets the threshold for entry into the virtual memory CD8 <sup>+</sup> T cell compartment by negatively regulating tonic TCR triggeringDOI 10.1101/582486
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