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Article

Immune regulatory functions of DOCK family proteins in health and disease.

Experimental cell research - 10 Sept 2013

Nishikimi Akihiko, Kukimoto-Niino Mutsuko, Yokoyama Shigeyuki, Fukui Yoshinori

Abstract excerpt

DOCK proteins constitute a family of evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho family of GTPases. Although DOCK family proteins do not contain the Dbl homology domain typically found in GEFs, they mediate the GTP-GDP exchange reaction through DHR-2 domain. Accumulating evidence indicates that the DOCK proteins act as major GEFs in varied biological settings. For example, DOCK2,...

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Source

Identifiers

PMID: 23911989
DOI: 10.1016/j.yexcr.2013.07.024

Genes

DOCK2
DOCK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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