Article
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
The Journal of experimental medicine - 24 Oct 2011
Randall Katrina L, Chan Stephanie S-Y, Ma Cindy S, Fung Ivan, Mei Yan, Yabas Mehmet, Tan Andy, Arkwright Peter D, Al Suwairi Wafaa, Lugo Reyes Saul Oswaldo, Yamazaki-Nakashimada Marco A, Garcia-Cruz Maria de la Luz, Smart Joanne M, Picard Capucine, Okada Satoshi, Jouanguy Emmanuelle, Casanova Jean-Laurent, Lambe Teresa, Cornall Richard J, Russell Sarah, Oliaro Jane, Tangye Stuart G, Bertram Edward M, Goodnow Christopher C
Abstract excerpt
In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both...
Topics
- Animals
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Division
- Cell Proliferation
- Cell Survival
- Guanine Nucleotide Exchange Factors
- Humans