Article

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection

2023-08-03

Abstract excerpt

The expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defence against infectious diseases. However, patients with these diseases are by definition rare. In addition, any analysis is complicated by treatments and co-morbid infections requiring the use of mouse models for detailed investigations. Here we develop a mouse model of DOCK2 immunodeficien...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25e45dee-ce10-5430-a960-4bf37b4c712f
DOI: 10.1101/2023.08.02.551154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infectionDOI 10.1101/2023.08.02.551154Read

The essential role of DOCK8 in humoral immunity.Semantic proximity Read

Insights into immunity from clinical and basic science studies of DOCK 8 immunodeficiency syndromeSemantic proximity Read

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.Semantic proximity Read

Dedicator of cytokinesis 8 (DOCK8) deficiency.Semantic proximity Read

Recent Advances in DOCK8 Immunodeficiency Syndrome.Semantic proximity Read

Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine.Semantic proximity Read

Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome.Semantic proximity Read

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.Semantic proximity Read

CRISPR/Cas-Based Gene Editing Strategies for DOCK8 Immunodeficiency SyndromeSemantic proximity Read

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain.Semantic proximity Read

A Saudi DOCK2-deficient patient with recurrent multiple infections including recalcitrant wartsSemantic proximity Read

The regulation of DOCK family proteins on T and B cellsSemantic proximity Read