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Article

DOCK family proteins: key players in immune surveillance mechanisms

16 Oct 2019

Abstract excerpt

Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK family proteins do not contain the Dbl homology domain typically found in other GEFs, they mediate the GTP-GDP exchange reaction through the DOCK homology region-2 (DHR-2) domain. In mammals, this family consists of 11 members, each of...

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PMID: 31630188
DOI: 10.1093/intimm/dxz067

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