Article

Significance of distinct liquid biopsy compartments in evaluating somatic mutations for targeted therapy selection in cancer of unknown primary

2022-10-21

Abstract excerpt

<title>Abstract</title> <p>Cancer of unknown primary (CUP) account for 2-5% of all cancer diagnoses, wherein standard investigations fail to reveal the original tumor site. Basket trials allocate targeted therapeutics based on actionable somatic mutations, independent of tumor entity. These trials, however, mostly rely on variants identified in tissue biopsies from solid tumors. Since liquid biopsies (LB) represe...

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Literature Corpus work: fbf684db-8920-59a1-ba0f-8e8f76fb3deb
DOI: 10.21203/rs.3.rs-2187431/v1

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