Article

Whole genome sequencing improves tissue of origin diagnosis and treatment options for cancer of unknown primary

2024-08-10

Abstract excerpt

Genomics holds promise for precision treatment and identifying the primary tissue of origin (TOO) in cases of cancer of unknown primary (CUP). We evaluated the feasibility and diagnostic superiority of whole genome and transcriptome sequencing (WGTS) over conventional panel testing in 72 patients using routine pathology samples. WGTS not only detected all reportable mutations identified by panel testing but also u...

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Literature Corpus work: 96baa604-01f7-5d94-a65e-cb07a958ff10
DOI: 10.1101/2024.08.09.24311642

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