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Article

Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Origin: Retrospective Molecular Classification Considering the CUPISCO Study Design.

The oncologist - 1 Mar 2021

Ross Jeffrey S, Sokol Ethan S, Moch Holger, Mileshkin Linda, Baciarello Giulia, Losa Ferran, Beringer Andreas, Thomas Marlene, Elvin Julia A, Ngo Nhu, Jin Dexter X, Krämer Alwin

Abstract excerpt

BACKGROUND: Carcinoma of unknown primary origin (CUP) accounts for 2%-5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care. CUPISCO (NCT03498521) is an ongoing randomized trial using comprehensive genomic profiling (CGP) to assign patients with CUP to targeted or immunotherapy treatment arms based on genomic profiling. We performed a retrospective analysis of CUP cases referred...

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Identifiers

PMID: 33219618
DOI: 10.1002/onco.13597
PMCID: PMC7930409

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