Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

20 May 2025

Abstract excerpt

Genomics can inform both tissue-of-origin (TOO) and precision treatments for patients with cancer of unknown primary (CUP). Here, we use whole genome and transcriptome sequencing (WGTS) for 72 patients and show diagnostic superiority of WGTS over panel testing (386–523 genes) in 71 paired cases. WGTS detects all reportable DNA features found by panel as well as additional mutations of diagnostic or therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Diagnosis and Treatment
Share to Oral and Maxillofacial Pathology
Share to Tumors and Oncological Cases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40393956
DOI: 10.1038/s41467-025-59661-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primaryPMID 40393956Read ↗

Whole genome sequencing improves tissue of origin diagnosis and treatment options for cancer of unknown primarySemantic proximity Read ↗

Real-world data analysis of patients with cancer of unknown primarySemantic proximity Read ↗

A prospective national precision medicine trial comparing blood and tissue profiling in patients with Cancer of Unknown Primary (CUPCOMP)Semantic proximity Read ↗

Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patientsSemantic proximity Read ↗

Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patientsSemantic proximity Read ↗

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation featuresSemantic proximity Read ↗

Comprehensive ctDNA Profiling Enables Tissue-of-Origin Prediction and Actionable Biomarker Detection in Cancer of Unknown PrimarySemantic proximity Read ↗

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation featuresSemantic proximity Read ↗

Significance of Distinct Liquid Biopsy Compartments in Evaluating Somatic Mutations for Targeted Therapy Selection in Cancer of Unknown Primary.Semantic proximity Read ↗

A comparison of DNA sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primarySemantic proximity Read ↗

CUPiD: A cfDNA methylation-based tissue-of-origin classifier for Cancers of Unknown PrimarySemantic proximity Read ↗

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.