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Article

Significance of Distinct Liquid Biopsy Compartments in Evaluating Somatic Mutations for Targeted Therapy Selection in Cancer of Unknown Primary.

Journal of gastrointestinal cancer - 1 Dec 2023

Kolbinger Fiona R, Bernard Vincent, Lee Jaewon J, Stephens Bret M, Branchi Vittorio, Raghav Kanwal P S, Maitra Anirban, Guerrero Paola A, Semaan Alexander

Abstract excerpt

PURPOSE: Cancer of unknown primary (CUP) accounts for 2-5% of all cancer diagnoses, wherein standard investigations fail to reveal the original tumor site. Basket trials allocate targeted therapeutics based on actionable somatic mutations, independent of tumor entity. These trials, however, mostly rely on variants identified in tissue biopsies. Since liquid biopsies (LB) represent the overall tumor genomic...

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PMID: 36862364
DOI: 10.1007/s12029-023-00922-7

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