Article

An integrated <i>in silico</i> - <i>in vitro</i> approach for identification of therapeutic drug targets for osteoarthritis

2021-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has emerged as a potential therapeutic strategy. Chondrocyte phenotype...

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Literature Corpus work: fbde7c74-151d-55e3-8812-cd8cb0cba459
DOI: 10.1101/2021.09.27.461207

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