Article

A high-impact <i>COL6A3</i> mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading

2022-12-19

Abstract excerpt

<h4>Objectives</h4> The etiology of osteoarthritis revolves around the interplay between genetic predisposition and perturbing environmental cues, such as mechanical stress. The pericellular matrix, with its hallmark proteins collagen type VI and fibronectin, surrounds chondrocytes and is critical in transducing the biomechanical cues. The objective is to study the functional effects of an OA disease-risk mutatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9eb5ba24-220d-5e35-afd7-fe2a35aa797f
DOI: 10.1101/2022.12.19.520461

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A high-impact <i>COL6A3</i> mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loadingDOI 10.1101/2022.12.19.520461Read

A damaging mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells.Semantic proximity Read

Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoidsSemantic proximity Read

Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis.Semantic proximity Read

Generation of a heterozygous COL2A1 (p.G1113C) hypochondrogenesis mutation iPSC line, MCRIi019-A-7, using CRISPR/Cas9 gene editing.Semantic proximity Read

Failed Cellular Surveillance Enables Pathogenic Matrix Deposition in a <i>COL2A1</i> -Related OsteoarthritisSemantic proximity Read

CRISPR-based epigenome and genome editing reveal novel roles for PLEC in cartilage biology, mechanobiology, and response to inflammationSemantic proximity Read

Modelling Osteoarthritis pathogenesis through Mechanical Loading in an Osteochondral Unit-on-ChipSemantic proximity Read

Emerging Gene-Editing Modalities for OsteoarthritisSemantic proximity Read

Single-cell RNA sequencing reveals the impact of mechanical loading on knee tibial cartilage in osteoarthritisSemantic proximity Read

Spatial transcriptomics defines the mechanisms of hiPSC-derived stem cell-mediated repair in human articular cartilageSemantic proximity Read

Identification of a family with van der Hoeve's syndrome harboring a novel COL1A1 mutation and generation of patient-derived iPSC lines and CRISPR/Cas9-corrected isogenic iPSCs.Semantic proximity Read