Article

In silico, in vitro, and in vivo models reveal EPHA2 as a target for decreasing inflammation and pathological endochondral ossification in osteoarthritis

2022-06-15

Abstract excerpt

Low-grade inflammation and pathological endochondral ossification are processes underlying the progression of osteoarthritis, the most prevalent joint disease worldwide. In this study, data mining on publicly available transcriptomic datasets revealed EPHA2, a receptor tyrosine kinase associated with cancer, to be associated with both inflammation and endochondral ossification in osteoarthritis. A computational mo...

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Literature Corpus work: c9af06f8-e9eb-51c4-a78a-881fa80fc23b
DOI: 10.1101/2022.06.12.495737

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