Article

Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autism

2018-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Loss of function mutations in CNTNAP2 cause a syndromic form of autism spectrum disorder (ASD) in humans and produce social deficits, repetitive behaviors, and seizures in mice. Yet, the functional effects of these mutations at the cellular and circuit level remain elusive. Using laser scanning photostimulation, whole-cell recordings, and electron microscopy, we found a dramatic decrease in func...

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Literature Corpus work: f545283a-c787-5ef8-ad1c-114ce2ab8b89
DOI: 10.1101/322388

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