Article

A cross-species link between mTOR-related synaptic pathology and functional hyperconnectivity in autism

2020-10-08

Abstract excerpt

Postmortem studies have revealed increased density of excitatory synapses in the brains of individuals with autism, with a putative link to aberrant mTOR-dependent synaptic pruning. Autism is also characterized by atypical macroscale functional connectivity as measured with resting-state fMRI (rsfMRI). These observations raise the question of whether excess of synapses cause aberrant functional connectivity in aut...

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Literature Corpus work: ffe91919-c581-516f-8ada-dba7982c5f22
DOI: 10.1101/2020.10.07.329292

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