Article

ASD-Associated <i>CNTNAP2</i> Variants Disrupt Neuronal Arborization Through Impaired Regulation by Ectodomain Shedding

2024-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Ectodomain shedding (ES) is a process by which a protease cleaves the extracellular portion of membrane-bound proteins, releasing soluble fragments that influence diverse cellular functions. ES is critical in neurodevelopment, plasticity, and neurodegenerative disorders, such as Alzheimer’s disease, and has recently been implicated in neurodevelopmental conditions, including autism spectrum diso...

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Literature Corpus work: e3d2459f-eff2-5162-8535-6509c7628dbe
DOI: 10.1101/2024.11.04.621898

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