Article

Diffusing protein binders to intrinsically disordered proteins

2024-07-16

Abstract excerpt

Proteins which bind intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could have considerable utility for therapeutic and diagnostic applications. However, a general methodology for targeting IDPs/IDRs has yet to be developed. Here, we show that starting only from the target sequence of the input, and freely sampling both target and binding prot...

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Literature Corpus work: 95b5c040-0d13-5b1c-9e9e-1ba9514932a8
DOI: 10.1101/2024.07.16.603789

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