Article

A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistance

2018-08-22

Abstract excerpt

<h4>SUMMARY</h4> Transcriptional profiling has revealed a diverse range of cancer cell states, however an understanding of their function has remained elusive. Using a combination of zebrafish melanoma modeling and human validation, we have identified a conserved stress-like state that confers intrinsic drug resistance. The stress-like state expresses genes such as fos , hsp70 and ubb , all required for adapta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbcfaf30-cbe3-5b45-9613-e7761f87ad19
DOI: 10.1101/396622

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistanceDOI 10.1101/396622Read

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual DiseaseSemantic proximity Read

Single-Nuclei Transcriptome Profiling Reveals Intra-Tumoral Heterogeneity and Characterizes Tumor Microenvironment Architecture in a Murine Melanoma Model.Semantic proximity Read

Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulationsSemantic proximity Read

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models.Semantic proximity Read

Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistanceSemantic proximity Read

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model <i>Xiphophorus</i> Provides Insights In Disease ControlSemantic proximity Read

Spatially resolved transcriptomics reveals the architecture of the tumor/microenvironment interfaceSemantic proximity Read

Therapeutic targeting of cellular stress responses in cancerSemantic proximity Read

Mechanical confinement governs phenotypic plasticity in melanomaSemantic proximity Read

Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanomaSemantic proximity Read

Specific <i>SOX10</i> enhancer elements modulate phenotype plasticity and drug resistance in melanomaSemantic proximity Read

An mRNA expression-based signature for oncogene-induced replication-stressSemantic proximity Read