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Therapeutic targeting of cellular stress responses in cancer

12 Oct 2018

Abstract excerpt

Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA-damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and...

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PMID: 30312004
DOI: 10.1111/1759-7714.12890

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