Article
Single-Nuclei Transcriptome Profiling Reveals Intra-Tumoral Heterogeneity and Characterizes Tumor Microenvironment Architecture in a Murine Melanoma Model.
International journal of molecular sciences - 18 Oct 2024
Parab Sushant, Sarlo Valery, Capellero Sonia, Palmiotto Luca, Bartolini Alice, Cantarella Daniela, Turi Marcello, Gullà Annamaria, Grassi Elena, Lazzari Chiara, Rubatto Marco, Gregorc Vanesa, Carnevale-Schianca Fabrizio, Olivero Martina, Bussolino Federico, Comunanza Valentina
Abstract excerpt
Malignant melanoma is an aggressive cancer, with a high risk of metastasis and mortality rates, characterized by cancer cell heterogeneity and complex tumor microenvironment (TME). Single cell biology is an ideal and powerful tool to address these features at a molecular level. However, this approach requires enzymatic cell dissociation that can influence cellular coverage. By contrast, single nucleus RNA...
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