Article

Long QT Syndrome modelling with cardiomyocytes derived from human-induced pluripotent stem cells

2019-01-01

Abstract excerpt

Long QT syndrome (LQTS) is a potentially severe arrhythmogenic disorder, associated with a prolonged QT interval and sudden death, caused by mutations in key genes regulating cardiac electrophysiology. Current strategies to study LQTS in vitro include heterologous systems or animal models. Despite their value, the overwhelming power of genetic tools has exposed the many limitations of these technologies. In 2010,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb937e63-7c62-5de5-8f5d-d7f9a4ed78e3
DOI: 10.15420/aer.2019.1.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long QT Syndrome modelling with cardiomyocytes derived from human-induced pluripotent stem cellsDOI 10.15420/aer.2019.1.1Read

Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Semantic proximity Read

Modeling long QT syndromes using induced pluripotent stem cells: current progress and future challenges.Semantic proximity Read

Induced Pluripotent Stem Cells in Congenital Long QT Syndrome: Research Progress and Clinical ApplicationsSemantic proximity Read

Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges.Semantic proximity Read

Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential.Semantic proximity Read

The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic DiseasesSemantic proximity Read

Modeling Inherited Cardiac DisordersSemantic proximity Read

Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.Semantic proximity Read

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmiasSemantic proximity Read

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes.Semantic proximity Read

Modelling the long QT syndrome with induced pluripotent stem cells.Semantic proximity Read

The Advantages, Challenges, and Future of Human-Induced Pluripotent Stem Cell Lines in Type 2 Long QT Syndrome.Semantic proximity Read