Article
Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Journal of the American Heart Association - 24 Mar 2018
El-Battrawy Ibrahim, Lan Huan, Cyganek Lukas, Zhao Zhihan, Li Xin, Buljubasic Fanis, Lang Siegfried, Yücel Gökhan, Sattler Katherine, Zimmermann Wolfram-Hubertus, Utikal Jochen, Wieland Thomas, Ravens Ursula, Borggrefe Martin, Zhou Xiao-Bo, Akin Ibrahim
Abstract excerpt
BACKGROUND: Short QT syndrome (SQTS), a disorder associated with characteristic ECG QT-segment abbreviation, predisposes affected patients to sudden cardiac death. Despite some progress in assessing the organ-level pathophysiology and genetic changes of the disorder, the understanding of the human cellular phenotype and discovering of an optimal therapy has lagged because of a lack of appropriate human cellular...
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