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Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.

International journal of cardiology - 15 Oct 2013

Ma Dongrui, Wei Heming, Zhao Yongxing, Lu Jun, Li Guang, Sahib Norliza Binte Esmail, Tan Teng Hong, Wong Keng Yean, Shim Winston, Wong Philip, Cook Stuart A, Liew Reginald

Abstract excerpt

BACKGROUND: Type 3 long QT syndrome (LQT3) is the third most common form of LQT syndrome and is characterized by QT-interval prolongation resulting from a gain-of-function mutation in SCN5A. We aimed to establish a patient-specific human induced pluripotent stem cell (hiPSC) model of LQT3, which could be used for future drug testing and development of novel treatments for this inherited disorder. METHODS AND...

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PMID: 23998552
DOI: 10.1016/j.ijcard.2013.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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