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Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential.

Cardiovascular research - 1 Dec 2018

van Mil Alain, Balk Geerthe Margriet, Neef Klaus, Buikema Jan Willem, Asselbergs Folkert W, Wu Sean M, Doevendans Pieter A, Sluijter Joost P G

Abstract excerpt

In the past few years, the use of specific cell types derived from induced pluripotent stem cells (iPSCs) has developed into a powerful approach to investigate the cellular pathophysiology of numerous diseases. Despite advances in therapy, heart disease continues to be one of the leading causes of death in the developed world. A major difficulty in unravelling the underlying cellular processes of heart disease is...

Topics

Action Potentials
Animals
Cell Differentiation
Genetic Predisposition to Disease
Heart Diseases
Hemodynamics
Heredity
Humans
Induced Pluripotent Stem Cells
Myocytes, Cardiac

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Ventricular Function

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PMID: 30169602
DOI: 10.1093/cvr/cvy208
PMCID: PMC6887927

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