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Article

The Advantages, Challenges, and Future of Human-Induced Pluripotent Stem Cell Lines in Type 2 Long QT Syndrome.

Journal of cardiovascular translational research - 1 Feb 2023

Cai Dihui, Zheng Zequn, Jin Xiaojun, Fu Yin, Cen Lichao, Ye Jiachun, Song Yongfei, Lian Jiangfang

Abstract excerpt

Type 2 long QT syndrome (LQT2) is the second most common subtype of long QT syndrome and is caused by mutations in KCHN2 encoding the rapidly activating delayed rectifier potassium channel vital for ventricular repolarization. Sudden cardiac death is a sentinel event of LQT2. Preclinical diagnosis by genetic testing is potentially life-saving.Traditional LQT2 models cannot wholly recapitulate genetic and...

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PMID: 35976484
DOI: 10.1007/s12265-022-10298-x

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