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Article

Modeling long QT syndromes using induced pluripotent stem cells: current progress and future challenges.

Trends in cardiovascular medicine - 1 May 2013

Friedrichs Stephanie, Malan Daniela, Sasse Philipp

Abstract excerpt

Long QT syndromes (LQTS) are a family of inherited monogenetic disorders caused by gain or loss-of-function mutations of cardiac ion channels and are characterized by a prolonged QT interval in the ECG. The disease-specific mutations lead to prolonged action potential durations and early after-depolarizations in cardiomyocytes potentially giving rise to triggered extrabeats and life-threatening arrhythmias in...

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Identifiers

PMID: 23266156
DOI: 10.1016/j.tcm.2012.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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