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A marked enhancement of a BLOC-1 gene, <i>pallidin</i> , associated with somnolent mouse models deficient in histamine transmission

2022-05-05

Abstract excerpt

Histamine (HA) and orexin (Ox, or hypocretin) neurons act distinctly and synergistically in wake control. A double knock out mouse genotype lacking both HA and Ox shows all sleep disorders of human narcolepsy. We identified in this mouse brain a sharp upregulation of a BLOC-1 gene, pallidin that is associated with dramatic changes in the balance of cholinergic and aminergic systems in mice and an enhanced sleep i...

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Literature Corpus work
b5988003-3dfb-5edd-8f5f-5f97bf2a8fcc
DOI
10.1101/2022.05.04.490425
Open publication

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A marked enhancement of a BLOC-1 gene, <i>pallidin</i> , associated with somnolent mouse models deficient in histamine transmissionDOI 10.1101/2022.05.04.490425
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