High-throughput discovery of genetic determinants of circadian misalignment.

doi:10.1371/journal.pgen.1008577

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Article

High-throughput discovery of genetic determinants of circadian misalignment.

PLoS genetics - 1 Jan 2020

Zhang Tao, Xie Pancheng, Dong Yingying, Liu Zhiwei, Zhou Fei, Pan Dejing, Huang Zhengyun, Zhai Qiaocheng, Gu Yue, Wu Qingyu, Tanaka Nobuhiko, Obata Yuichi, Bradley Allan, Lelliott Christopher J, Nutter Lauryl M J, McKerlie Colin, Flenniken Ann M, Champy Marie-France, Sorg Tania, Herault Yann, Angelis Martin Hrabe De, Durner Valerie Gailus, Mallon Ann-Marie, Brown Steve D M, Meehan Terry, Parkinson Helen E, Smedley Damian, Lloyd K C Kent, Yan Jun, Gao Xiang, Seong Je Kyung, Wang Chi-Kuang Leo, Sedlacek Radislav, Liu Yi, Rozman Jan, Yang Ling, Xu Ying

Abstract excerpt

Circadian systems provide a fitness advantage to organisms by allowing them to adapt to daily changes of environmental cues, such as light/dark cycles. The molecular mechanism underlying the circadian clock has been well characterized. However, how internal circadian clocks are entrained with regular daily light/dark cycles remains unclear. By collecting and analyzing indirect calorimetry (IC) data from more than...

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PMID: 31929527
DOI: 10.1371/journal.pgen.1008577
PMCID: PMC6980734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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