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Article

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

The Journal of clinical investigation - 1 Mar 2018

Polex-Wolf Joseph, Lam Brian Yh, Larder Rachel, Tadross John, Rimmington Debra, Bosch Fàtima, Cenzano Verónica Jiménez, Ayuso Eduard, Ma Marcella Kl, Rainbow Kara, Coll Anthony P, O'Rahilly Stephen, Yeo Giles Sh

Abstract excerpt

Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. Mice with a microdeletion encompassing the Snord116 cluster of noncoding RNAs encoded within the Prader-Willi minimal deletion critical region have previously been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29376887
DOI: 10.1172/JCI97007
PMCID: PMC5824864

Genes

NHLH2
PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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