Article

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity

2021-12-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Thrombosis of the lung micro-vasculature is a characteristic of COVID-19 disease, which is observed in large excess compared to other forms of acute respiratory distress syndrome and thus suggests a trigger for thrombosis endogenous to the lung. Our recent work has shown that the SARS-CoV-2 Spike protein activates the cellular TMEM16F chloride channel and scramblase. Through...

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Literature Corpus work: 8c5eab3a-8a90-54c8-8793-f635f7931f75
DOI: 10.1101/2021.12.14.472668

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