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CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis

21 Aug 2023

Abstract excerpt

Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein are associated with coagulation disorders of COVID-19 patients, and intravenous administration of the E protein is able to potentiate thrombosis in mice. Through protein pull-down and mass spectrometry, we...

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PMID: 37604832
DOI: 10.1038/s41467-023-40824-7

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