SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)

Abstract excerpt

Although progressive respiratory failure is the primary cause of death in patients with COVID-19, thromboembolic complications further increased the mortality rates. Endothelial dysfunction, a pro-inflammatory and pro-coagulant state characterized by increased interaction with leukocytes and platelets, is reported to play a key role in COVID-19-associated thrombosis; 1 however, its underlying mechanism remains...

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