Article

SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis

2025-01-03

Abstract excerpt

<title>Abstract</title> <p>COVID-19 associated coagulation abnormalities and thrombosis are life-threatening complications after SARS-CoV-2 infection. However, the underlying mechanisms are unclear. Here, we found that SARS-CoV-2 spike (S) protein induced excessive reactive oxygen species (ROS) production, disrupting mitochondrial dynamics and causing endothelial cells damage, thereby promoting thrombogenesis. Me...

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Literature Corpus work: 76caac86-8146-562b-b743-b7d530e52ee9
DOI: 10.21203/rs.3.rs-5572297/v1

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SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesisDOI 10.21203/rs.3.rs-5572297/v1Read

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