Article

Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein

2024-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Increasing efforts have been made to elucidate how genetic and environmental factors interact in Parkinson’s disease (PD). In the present study, we assessed the development of symptoms on a genetic PD rat model that overexpresses human α-synuclein ( Snca +/+ ) at a presymptomatic age, exposed to a pro-inflammatory insult by intraperitoneal injection of lipopolysaccharide (LPS), using immunohist...

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Literature Corpus work: fb621764-3207-5e2c-92df-ea545dcd46fc
DOI: 10.1101/2024.01.30.577912

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