Article

Association between lipoprotein(a),<i>LPA</i>genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular events

2023-09-23

Abstract excerpt

<h4>Background</h4> Cohort studies have demonstrated associations between calcific aortic valve disease (CAVD) and Lp(a). As Lp(a) is almost entirely genetically determined, with the increasing clinical availability of genetic information, we aimed to determine if Lp(a), when predicted from genetic data, is associated with CAVD and major adverse cardiovascular events (MACE). <h4>Methods</h4> Patients undergoing co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb6095fa-ea0d-597f-a7bb-f91117710aa7
DOI: 10.1101/2023.09.20.23295872

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Association between lipoprotein(a),<i>LPA</i>genetic risk score, aortic valve disease, and subsequent major adverse cardiovascular eventsDOI 10.1101/2023.09.20.23295872Read

Clinical Utility of Lipoprotein(a) and <i>LPA</i> Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular DiseaseSemantic proximity Read

Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry.Semantic proximity Read

Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events.Semantic proximity Read

Lipoprotein (a): An Update on a Marker of Residual Risk and Associated Clinical Manifestations.Semantic proximity Read

Elevated Lipoprotein(a) Levels, LPA Risk Genotypes, and Increased Risk of Heart Failure in the General Population.Semantic proximity Read

Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.Semantic proximity Read

The biology of lipoprotein(a): From genetics to molecular mechanismsSemantic proximity Read

Genetics and Pathophysiological Mechanisms of Lipoprotein(a)-Associated Cardiovascular Risk.Semantic proximity Read

Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide Mendelian randomization studySemantic proximity Read

Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association.Semantic proximity Read

Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene regionSemantic proximity Read

Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records.Semantic proximity Read