Article
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2022
Reyes-Soffer Gissette, Ginsberg Henry N, Berglund Lars, Duell P Barton, Heffron Sean P, Kamstrup Pia R, Lloyd-Jones Donald M, Marcovina Santica M, Yeang Calvin, Koschinsky Marlys L
Abstract excerpt
High levels of lipoprotein(a) [Lp(a)], an apoB100-containing lipoprotein, are an independent and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms associated with increased atherogenesis, inflammation, and thrombosis. Lp(a) is predominantly a monogenic cardiovascular risk determinant, with ≈70% to ≥90% of interindividual heterogeneity in levels being genetically determined. The 2...
Topics
- American Heart Association
- Atherosclerosis
- Biomarkers
- Consensus
- Evidence-Based Medicine
- Genetic Predisposition to Disease
- Heart Disease Risk Factors
- Humans
- Hypolipidemic Agents
- Lipoprotein(a)
- Prevalence
- Prognosis