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Article

Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records.

JAMA cardiology - 1 Jan 2018

Chen Hao Yu, Dufresne Line, Burr Hannah, Ambikkumar Athithan, Yasui Niko, Luk Kevin, Ranatunga Dilrini K, Whitmer Rachel A, Lathrop Mark, Engert James C, Thanassoulis George

Abstract excerpt

Importance: Elevated lipoprotein(a) levels are a risk factor for aortic stenosis (AS). However, a large-scale replication of associations between LPA variants and AS, their interactions with risk factors, and the effect of multiple risk alleles is not well established. Objective: To replicate the association between LPA variants with AS and identify subgroups who are at higher risk of developing AS. Design,...

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Identifiers

PMID: 29128868
DOI: 10.1001/jamacardio.2017.4266
PMCID: PMC5833523

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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