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The biology of lipoprotein(a): From genetics to molecular mechanisms

3 Oct 2025

Abstract excerpt

BACKGROUND: Lipoprotein(a) [Lp(a)] is a primarily genetically determined, low-density lipoprotein-like particle that plays an important role in atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). Despite optimal control of traditional lipid levels, elevated lipoprotein(a) [Lp(a)] remains a significant contributor to residual cardiovascular risk, affecting up to 20% of the...

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PMID: 41042035
DOI: 10.1111/eci.70133

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