Article

DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC

2020-05-26

Abstract excerpt

H3.3 variant is a versatile histone important for development and disease. We report a DNA methylation dependent decrease of histone H3 variant H3.3 in hepatocellular carcinoma (HCC) development and an increase in the level of the H3.2 variant. The loss of H3.3 correlates with a decrease in the histone PTMs associated with active transcription. The overexpression of H3.3 and H3.2 did not affect global PTMs and cel...

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Literature Corpus work: fb52d089-0b3a-5a0f-94b0-6672b73a7f0a
DOI: 10.1101/2020.05.23.112516

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DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCCDOI 10.1101/2020.05.23.112516Read

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