Article
Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.
Cellular and molecular life sciences : CMLS - 1 Sept 2014
Deb Moonmoon, Kar Swayamsiddha, Sengupta Dipta, Shilpi Arunima, Parbin Sabnam, Rath Sandip K, Londhe Vedang A, Patra Samir Kumar
Abstract excerpt
The dynamic nature of chromatin and its myriad modifications play a crucial role in gene regulation (expression and repression) during development, cellular survival, homeostasis, ageing, and apoptosis/death. Histone 3 lysine 4 methylation (H3K4 methylation) catalyzed by H3K4 specific histone methyltransferases is one of the more critical chromatin modifications that is generally associated with gene activation....
Topics
- Amino Acid Sequence
- Chromatin
- Chromatin Assembly and Disassembly
- Epigenomics
- Gene Expression Regulation
- Genetic Variation
- Genome
- Histones
- Humans
- Methylation