Article

<i>Cis-topic</i> modelling of single-cell epigenomes

2018-07-16

Abstract excerpt

Single-cell epigenomics provides new opportunities to decipher genomic regulatory programs from heterogeneous samples and dynamic processes. We present a probabilistic framework called cisTopic, to simultaneously discover “cis-regulatory topics” and stable cell states from sparse single-cell epigenomics data. After benchmarking cisTopic on single-cell ATAC-seq data, single-cell DNA methylation data, and semi-simul...

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Literature Corpus work: fb392377-45ff-522f-b960-55e1f18519d0
DOI: 10.1101/370346

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