Article

Endogenous recapitulation of Alzheimer’s disease neuropathology through human 3D direct neuronal reprogramming

2023-05-25

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder that primarily affects elderly individuals, and is characterized by hallmark neuronal pathologies including extracellular amyloid-β (Aβ) plaque deposition, intracellular tau tangles, and neuronal death. However, recapitulating these age-associated neuronal pathologies in patient-derived neurons has remained a significant challenge, especially for late-onset...

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Identifiers and source

Literature Corpus work: 26176929-40c9-577e-abbb-0060a8e38ba4
DOI: 10.1101/2023.05.24.542155

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