Article
An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction.
Glia - 1 Apr 2011
Desai Maya K, Guercio Brendan J, Narrow Wade C, Bowers William J
Abstract excerpt
White matter pathology has been documented in the brains of familial Alzheimer's disease (FAD)-afflicted individuals during presymptomatic and preclinical stages of AD. How these defects in myelination integrity arise and what roles they may play in AD pathophysiology have yet to be fully elucidated. We previously demonstrated that triple-transgenic AD (3xTg-AD) mice, which harbor the human amyloid precursor...
Topics
- Amyloid beta-Peptides
- Analysis of Variance
- Animals
- Blotting, Western
- Cell Differentiation
- Cell Line
- Flow Cytometry
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinase 3 beta
- Immunohistochemistry
- Mice
- Mice, Transgenic
- Mutation
- Myelin Sheath